AdvaGenix: Leaders in Next Generation Sequencing

AdvaGenix is the first all-encompassing preimplantation genetics laboratory that employs next generation sequencing for all testing.

AdvaGenix is especially attractive to IVF clinics desiring the use of Next Generation Sequencing as the testing strategy for their patients and their preimplantation embryos.

We also offer patients the ability to forgo embryo freezing and transfer the genetically normal embryos the day after embryo biopsy.

Traditional DNA sequencing, called Sanger sequencing, is a method that permits the sequence analysis of between approximately 30 base pairs to 800 base pairs from one DNA fragment as compared to a reference genome. It is a very accurate method for a specific DNA sequence. Its applications include determining a specific DNA mutation or variant but it cannot also simultaneously determine chromosome abnormalities.

The benefits of next generation sequencing

The high demand for affordable sequencing has driven the development of high throughput sequencing, which is called Next Generation sequencing. In contrast to traditional Sanger sequencing, Next Generation Sequencing concurrently sequences thousands or millions of DNA fragments ranging in sizes from approximately 150 base pairs to over 600 base pairs.

The key difference versus Sanger sequencing is the simultaneous sequencing of millions of fragments of DNA, their comparison to a reference genome, the ability to determine mitochondrion copy number and to simultaneously determine chromosome abnormalities, ALL at the same time.